Research

Ger Strous' Group

Our major aim is to elucidate the molecular mechanisms that determine the Growth Hormone (GH) sensitivity of cells. Cells of the human body contain GH receptors (GHR). Upon GH binding these receptors initiate signal transduction that results in the expression of genes that involved in anabolic processes...

Teresa Żołądek’s Group

The goal of our project is to find the role of protein ubiqutination in regulation of process of autophagy, which contributes in programmed cell death, aging and neurodegeneration. Process of autophagy is conserved in evolution, therefore in our studies we use the model eukaryotic organism, the yeast Saccharomyces cerevisiae.

Titia Sixma's Group

Our work is focusing on the structural and functional characterization of proteins belonging to the Polycomb Repressive Complex 1(PRC1). The PRC1 is a large multimeric complex consisting of proteins belonging to many different families.

SyMO-Chem BV

SyMO-Chem is a dedicated chemical contract research company that is active in the fields of organic, polymer and analytical chemistry. In assignment of its clients, and also in collaboration with those clients, complex molecules are designed and synthesized.

Maria Masucci's Group

Manipulation of the ubiquitin proteasome system (UPS) is emering as a common theme in viral pathogenesis. There are now enough examples on functional homologs of UPS enzymes encoded in some of the viral genomes suggesting that a systematic identification of these viral products may provide new insights into virus-host-cell interactions...

Pier-Paolo Di Fiore's Group

Our aim is to elucidate the implications of mono- and oligo-ubiquitinated proteins in a variety of intracellular signaling pathways, and to understand how ubiquitin- and UBL molecule-dependent post-translational protein modifications play a regulatory role in basic cellular processes and, once functionally deregulated, in human pathology. In particular, we are focusing...

Aaron Ciechanover's Group

The group is involved in studying basic aspects in the involvement of the ubiquitin system in the mechanisms that underlie malignant transformation. Within this context, we are studying several subjects. We have identified novel E3 that targets Myc and study its biological significance and role in regulating this growth promoting factor...

DDF Research Group

DDF is involved in several drug discovery programs including finding new cures for prostate cancer, dendritic based cancer vaccines, osteoporosis and Alzheimer. Furthermore, the company is actively seeking for drugs to facilitate drug transport over the blood brain barrier. The company is affiliated with the research group of Ger Strous to develop drugs...

Dieter Wolf's Group

Dieter H. Wolf’s group is concerned with intracellular regulation and protein quality control via the ubiquitin proteasome system. The yeast Saccharomyces cerevisiae serves as a model eukaryote for these studies. As the "housekeeping” functions of eukaryotic cells are highly conserved from yeast to man, the easy amenability of yeast to all biological tools...

Frauke Melchior's Group

Research in our group centers around posttranslational modification with small ubiquitin-related proteins of the SUMO family. Like ubiquitin, these proteins can be covalently and reversibly linked to other proteins. Attachment of SUMO does not lead to degradation, and instead serves...

Rosine Haguenauer-Tsapis' Group

We are studying intracellular traffic along the endocytic and Golgi to vacuole trafficking pathways using budding yeast as a model organism. We largely contributed to the understanding that the main internalization signal in yeast is the modification of target plasma membrane proteins by covalent addition of ubiquitin,...

Stefan Jentsch's Group

Our laboratory has a long-standing interest in protein modification by ubiquitin and ubiquitin-like proteins. Our research focuses primarily on functional aspects. We identify from yeast and mammalian cells the enzymatic components of these systems, clone...